Human TARC (CCL17) ELISA

TARC (thymus and activation-regulated chemokine), also known as C-C motif chemokine ligand 17 (CCL17), is expressed in the thymus and is produced by dendritic cells, endothelial cells, keratinocytes, and fibroblasts¹. TARC has affinity as a ligand for the C-C chemokine receptors CCR4 and CCR8 inducing Th2-dominant inflammatory reactions.

TARC has an important role in allergic diseases such as atopic dermatitis and bronchial asthma^2,3. High serum concentrations of TARC are observed in patients with atopic dermatitis, and its concentration reflects the disease activity ^4,5. The concentration of TARC is also reported to be elevated in sputum of patients with bronchial asthma⁶, and TARC may have potential as a therapeutic target. In clinical practice, TARC is useful also in selection of patients requiring new therapies of atopic dermatitis or asthma.⁷

Enzyme Immunoassay for the quantitative determination of TARC in human serum.

RESOURCES

1. Saeki, H. & Tamaki, K. Thymus and activation regulated chemokine (TARC)/CCL17 and skin diseases. J. dermatological Sci. 43, 75–84, (2006)
2. Hamilton JD et al. Dupilumab suppresses type 2 inflammatory biomarkers across multiple atopic, allergic diseases. Clin Exp Allergy 51(7):915-931 (2021)
3. Yamada A, Kiryu K, Takashino S, Yoshida M, Takeichi T, Kitamura O. Diagnostic value of serum thymus and activation-regulated chemokine (TARC) in fatal asthma. Forensic Sci Int. 365:112276 (2024)
4. Kakinuma, T. et al. Thymus and activation-regulated chemokine in atopic dermatitis: Serum thymus and activation-regulated chemokine level is closely related with disease activity. J. allergy Clin. immunology 107, 535–541, (2001).
5. Dekkers C et al. Tralokinumab Treatment in Adult Atopic Dermatitis Patients: 28-Week Evaluation of Clinical Effectiveness, Safety, Serum Proteins and Total IgE Levels. Allergy. Ahead of print. https://doi.org/10.1111/all.16414 (2024)
6. Sekiya, T. et al. Increased levels of a TH2-type CC chemokine thymus and activation-regulated chemokine (TARC) in serum and induced sputum of asthmatics. Allergy 57, 173–177 (2002)
7. Kataoka Y. Thymus and activation-regulated chemokine (CCL17) as a clinical biomarker in atopic dermatitis: significance and limitations in the new treatment era. Front Allergy 5:1473902 (2025)