Apolipoprotein M is a secreted 25kDa member of the lipocalin protein family. Apo M is predominantly expressed in the mature liver and kidney and plays a role in lipid metabolism. It is found associated with high density lipoproteins (HDL) in human plasma and to a lesser extent with low density lipoproteins (LDL), triglyceride-rich lipoproteins (TGLRP) and chylomicrons and is involved in lipid transport. It plays an important role in the anti-atherogenic function of HDL by influencing the accumulation of cholesterol in these particles and reverse cholesterol transport. ApoM was found to increase the capacity of HDL to induce cholesterol efflux from macrophage foam cells and to inhibit LDL oxidation. ApoM also might be a useful biomarker for predicting the progression of diabetic nephropathy, and the ApoM/S1P-S1P1 axis might serve as a novel therapeutic target for preventing the development/progression of diabetic nephropathy.
Enzyme Immunoassay for the quantitative determination of Apolipoprotein M (ApoM, Apo M) in human serum and plasma.
RESOURCES
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- Yao Mattison I, Christoffersen C: Apolipoprotein M and its impact on endothelial dysfunction and inflammation in the cardiovascular system. Atherosclerosis. 2021 Oct;334:76-84
