Clusterin, also known as apolipoprotein J, is a widely expressed heterodimeric glycoprotein, important in tumorigenesis, apoptosis and immunoregulation. Clusterin is a cellular chaperon that stabilizes stressed proteins in a folding-competent state and protein has also been implicated in programmed cell death. Another defining prominent of clusterin is its induction in many severe physiological disturbance states including kidney degenerative diseases, prostate and vesicle carcinogenesis, ovarian cancer, and several neurodegenerative conditions (Alzheimer’s disease) [1-3].
Recent findings demonstrate that high serum clusterin levels are connected to oxidation stress, vascular damage, sepsis and related mortality or significantly lower serum clusterin was observed in dogs with multicentric lymphoma (MLSA) [4,5].
Urinary clusterin has been approved as a biomarker to monitor drug-induced proximal tubular injury in rats by the U.S. Food and Drug Administration and the European Medicines Agency. Furthermore, urinary clusterin may also help to differentiate between tubular and glomerular forms of proteinuria [5-7].
The BA2007 Canine/Feline Clusterin ELISA is a sandwich enzyme immunoassay for the quantitative measurement of canine/ feline clusterin in urine, serum and plasma.
RESOURCES
- Rodríguez-Rivera C, Garcia MM, Molina-Álvarez M, González-Martín C, Goicoechea C. Clusterin: Always protecting. Synthesis, function and potential issues. Biomed Pharmacother. 2021 Feb;134:111174.
- Zhang LY, Ying WT, Mao YS, He HZ, Liu Y, Wang HX, Liu F, Wang K, Zhang DC, Wang Y, Wu M, Qian XH and Zhao XH: Loss of Clusterin both in serum and tissue correlates with the tumorogenesis of esophageal squamous cell carcinoma via proteomics approaches. World J Gastroenterol 2003; 9:650-654
- Strochi P, Smith MA, Perry G, Tamagno E, Danni O, Pession A, Gaiba A, Dozza B: Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells. Neurobiol. of Aging 2006; 27:1588-1594.
- McNaught, Katie A.; Morris, Joanna S.; McLaughlin, Mark. Preliminary assessment of serum clusterin as a potential biomarker for canine lymphoma. Veterinary and Comparative Oncology, 2020 Sep;18(3):292-302.
- Dieterle F, Perentes E, Cordier A, Roth DR, Verdes P, Grenet O, Pantano S, Moulin P, Wahl D, Mahl A, End P, Staedtler F, Legay F, Carl K, Laurie D, Chibout SD, Vonderscher J, Maurer G. Urinary clusterin, cystatin C, beta2-microglobulin and total protein as markers to detect drug-induced kidney injury. Nat Biotechnol. 2010 May;28(5):463-9
- García-Martínez JD, Tvarijonaviciute A, Cerón JJ, Caldin M, Martínez-Subiela S. Urinary clusterin as a renal marker in dogs. J Vet Diagn Invest. 2012 Mar;24(2):301-6.
- Ishii A, Sakai Y, and Nakamura A: Molecular pathological evaluation of clusterin in a rat model of unilateral ureteral obstruction as a possible biomarker of nephrotoxicity. Toxicologic Pathology 2007; 35:376-382.
- Hidaka S, Kränzlin B, Gretz N, Witzgall R: Urinary Clusterin levels in the rat correlate with the severity of tubular damage and may help to differentiate between glomerular and tubular injuries. Cell Tissue Res. 2002; 310:289-296
