Osteopontin (OPN), a secreted multifunctional phosphoprotein, is a member of the small integrin-binding ligand N-linked glycoprotein (SIBLING) family of cell matrix proteins and participates in many biological activities. OPN has been demonstrated to be closely related to the occurrence and development of many bone-related diseases, such as osteoporosis, rheumatoid arthritis, and osteosarcoma.1 Besides that, it functions as a proinflammatory cytokine and promotes cell-mediated immune responses, and also has protective functions such as biomineralization [20,22,23] and wound healing, and is also a strong predictor of adverse outcomes in patients with CVDs [30–32]. Thus, OPN is not only a risk factor but also a potential therapeutic target for CVDs.2
Enzyme Immunoassay for the quantitative determination of Osteopontin in human serum and plasma.
RESOURCE
- Si J, Wang C, Zhang D, Wang B, Zhou Y. Osteopontin in Bone Metabolism and Bone Diseases. Med Sci Monit. 2020 Jan 30;26:e919159. doi: 10.12659/MSM.919159. PMID: 31996665; PMCID: PMC7003659.
- Shirakawa K, Sano M. Osteopontin in Cardiovascular Diseases. Biomolecules. 2021 Jul 16;11(7):1047. doi: 10.3390/biom11071047. PMID: 34356671; PMCID: PMC8301767
