Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases, responsible for the integrity of the basement membrane (BM) via degradation of extracellular matrix and BM components.1 MMPs are presented in various types of cells, including cardiomyocytes, cerebral neurons, hepatocytes, and many others, thus influencing various processes.
MMP-2, also called gelatinase A, is reported to play a crucial intracellular role where it cleaves several sarcomeric proteins inside cardiac myocytes during oxidative stress-induced injury.2 Elevated levels of MMP-2 (combined with MMP-9) are also associated with highly tumorigenic cancers, such as breast, gastric.
Enzyme Immunoassay for the quantitative determination of Matrix metalloproteinase 2 (MMP-2) in human serum and plasma.
RESOURCES
- Łukaszewicz-Zając M, Mroczko B, Słowik A. Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in amyotrophic lateral sclerosis (ALS). J Neural Transm (Vienna). 2014 Nov;121(11):1387-97. doi: 10.1007/s00702-014-1205-3. Epub 2014 Jul 22. PMID: 25047909; PMCID: PMC4210652.
- Bassiouni W, Ali MAM, Schulz R. Multifunctional intracellular matrix metalloproteinases: implications in disease. FEBS J. 2021 Dec;288(24):7162-7182. doi: 10.1111/febs.15701. Epub 2021 Jan 22. PMID: 33405316.
