Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases, responsible for the integrity of the basement membrane (BM) via degradation of extracellular matrix and BM components. MMPs are presented in various types of cells, including cardiomyocytes, cerebral neurons, hepatocytes, and many others, thus influencing various processes.
MMP-3, also called stromelysin 1, is reported to be found in the cytosol of dopaminergic cells where its activation under stress conditions contributes to neuronal degradation.1 In chondrocytes, nuclear MMP-3 is suggested to be involved in the development of inflammatory arthritic diseases.2 Matrix metalloproteinase-3 (MMP-3) is implicated in the formation of atherosclerotic plaques, and the MMP-3 −1612 5A/6A polymorphism is associated with myocardial infarction (MI) and stable coronary artery disease (CAD).3
Enzyme Immunoassay for the quantitative determination of Matrix metalloproteinase 3 (MMP-3) in human serum and plasma.
RESOURCES
- Choi DH, Kim EM, Son HJ, Joh TH, Kim YS, Kim D, Flint Beal M & Hwang O (2008) A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells. J Neurochem 106, 405–415.
- Eguchi T, Kubota S, Kawata K, Mukudai Y, Uehara J, Ohgawara T, Ibaragi S, Sasaki A, Kuboki T & Takigawa M (2008) Novel transcription-factor-like function of human matrix metalloproteinase 3 regulating the CTGF/CCN2 gene. Mol Cell Biol 28, 2391–2413.
- Moolhuijsen LME, Visser JA. Anti-Müllerian Hormone and Ovarian Reserve: Update on Assessing Ovarian Function. J Clin Endocrinol Metab. 2020 Nov 1;105(11):3361–73. doi: 10.1210/clinem/dgaa513. PMID: 32770239; PMCID: PMC7486884.
- Samnegård A, Silveira A, Lundman P, Boquist S, Odeberg J, Hulthe J, McPheat W, Tornvall P, Bergstrand L, Ericsson CG, Hamsten A, Eriksson P. Serum matrix metalloproteinase-3 concentration is influenced by MMP-3 -1612 5A/6A promoter genotype and associated with myocardial infarction. J Intern Med. 2005 Nov;258(5):411-9. doi: 10.1111/j.1365-2796.2005.01561.x. PMID: 16238676.
