Human Beta-2 Microglobulin ELISA

Urinary excretion of Beta 2-microglobulin (beta 2M) is a widely used test of renal proximal tubular function.¹ Proximal tubular dysfunction leads to an increased urinary concentration.² The serum level of beta 2-microglobulin is determined by the glomerular filtration rate and the rate of synthesis. Increased production, with raised serum levels, is sometimes observed in malignancy–mainly at an advanced state.² A strong correlation between lupus nephritis (LN), disease activity, and serum beta 2-microglobulin (b2MG) was observed. Serum b2MG level can be used as a valuable predictor for LN, clinical disease activity, and damage score.³

Enzyme Immunoassay for the quantitative determination of Beta 2-microglobulin in human serum, plasma, and urine.

RESOURCES

1. Davey PG, Gosling P. beta 2-Microglobulin instability in pathological urine. Clin Chem. 1982 Jun;28(6):1330-3. PMID: 6176371.
2. Karlsson FA, Wibell L, Evrin PE. beta 2-Microglobulin in clinical medicine. Scand J Clin Lab Invest Suppl. 1980;154:27-37. PMID: 6163193.
3. Gamal DM, Badr FM, Taha SIAEF, Moustafa NM, Teama MAEM. Serum beta-2 microglobulin as a predictor of nephritis, disease activity, and damage score in systemic lupus erythematosus: a cross-sectional study. Rheumatol Int. 2022 Oct 7. doi: 10.1007/s00296-022-05221-1. Epub ahead of print. PMID: 36205758.