Retinol-binding Protein 4 (RBP4) is a member of the lipocalin family and the major transport protein of the hydrophobic molecule retinol, also known as vitamin A, in the circulation.1 Retinol-binding Protein 4 (RBP4) is elevated in serum and adipose tissue (AT) in obesity-induced insulin resistance and correlates inversely with insulin-stimulated glucose disposal. Serum RBP4 levels correlated inversely with glucose disposal and insulin-mediated suppression of lipolysis, FFA, and EGP.2
High levels of serum RBP4 are associated with chronic kidney disease (CKD) and urine BRP4 is the most sensitive biomarker of proximal renal tubule function.
Enzyme Immunoassay for the quantitative determination of Retinol-binding Protein 4 (RBP4) in human serum and plasma.
RESOURCES
- Steinhoff JS, Lass A, Schupp M. Biological Functions of RBP4 and Its Relevance for Human Diseases. Front Physiol. 2021 Mar 11;12:659977. doi: 10.3389/fphys.2021.659977. PMID: 33790810; PMCID: PMC8006376.
- Kilicarslan M, de Weijer BA, Simonyté Sjödin K, Aryal P, Ter Horst KW, Cakir H, Romijn JA, Ackermans MT, Janssen IM, Berends FJ, van de Laar AW, Houdijk AP, Kahn BB, Serlie MJ. RBP4 increases lipolysis in human adipocytes and is associated with increased lipolysis and hepatic insulin resistance in obese women. FASEB J. 2020 May;34(5):6099-6110. doi: 10.1096/fj.201901979RR. Epub 2020 Mar 13. PMID: 32167208; PMCID: PMC7317205.
