Angiopoietin-like Protein 4 (ANGPTL-4) is a glycoprotein structurally belonging to the angiopoietin/Angptl family and is ubiquitously expressed in human tissues. The highest expression levels in humans are found in liver, followed by the small intestine, adipose tissue, and heart. Angptl4 is strongly induced by fasting in white adipose tissue and liver and has a role in the regulation of lipid metabolism, particularly as an inhibitor of lipoprotein lipase activity. Angptl4 has been implicated in the development of hypertriglyceridemia.
Enzyme Immunoassay for the quantitative determination of Angiopoietin-like Protein 4 (ANGPTL-4) in human serum and plasma.
RESOURCES
- Sukonina V, Lookene A, Olivecrona T, Olivecrona G.: Angiopoietin-like protein 4 converts lipoprotein lipase to inactive monomers and modulates lipase activity in adipose tissue. PNAS November 14, 2006 vol. 103 no. 46 17450-17455
- Xu A., Lam M. C., Chan K. W., Wang Y., Zhang J., Hoo R. L., Xu J. Y., Chen B., Chow W. S., Tso A. W., Lam K. S. (2005): Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proc. Natl. Acad. Sci. U.S.A. 102, 6086–6091
- Stejskal D, Karpisek M, Reutová H, Humenanská V, Petzel M, Kusnierová P, Vareka I, Vareková R, Stejskal P. Angiopoietin-like protein 4: development, analytical characterization, and clinical testing of a new ELISA. Gen Physiol Biophys. 2008 Mar;27(1):59-63.
